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【Daniel RAZANSKY】
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Advanced Imaging
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Research Articles
Highly sensitive miniature needle PVDF-TrFE ultrasound sensor for optoacoustic microscopy
Yu-Hang Liu
1,2
Alexey Kurnikov
3
Weiye Li
1,2
Pavel Subochev
3
Daniel Razansky
1,2,*
Author Affiliations
Abstract
1
University of Zurich, Institute of Pharmacology and Toxicology and Institute for Biomedical Engineering, Faculty of Medicine, Zurich, Switzerland
2
ETH Zurich, Institute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, Zurich, Switzerland
3
Russian Academy of Sciences, Institute of Applied Physics, Nizhny Novgorod, Russia
A wideband sensitive needle ultrasound sensor based on a polarized PVDF-TrFE copolymer piezoelectric film has been developed, which is capable of providing a noise equivalent pressure of 14 Pa and a uniform frequency response ranging from 1 to 25 MHz. Its high sensitivity (1.6 μV / Pa) and compact size were achieved by capitalizing on the large electromechanical coupling coefficient of PVDF-TrFE and minimizing parasitic capacitance in a two-stage amplifier structure. The detection sensitivity of the newly designed sensor outperformed commercially available hydrophones with an equivalent sensing element area by a factor of 9. The sensor has been successfully integrated into a light scanning optoacoustic microscopy (OAM) system with a limited working space. Submicrometer resolution images were subsequently attained from living mice without employing signal averaging. The miniature sensor design can readily be integrated into various OAM systems and further facilitate multimodal imaging system implementations.
photoacoustic
microscopy
hydrophone
in vivo imaging
multimodality
miniature
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Advanced Photonics Nexus
2023, 2(5): 056006
Imaging Systems, Microscopy, and Displays
Single-sweep volumetric optoacoustic tomography of whole mice
Sandeep Kumar Kalva
1,2
Xose Luis Dean-Ben
1,2
Daniel Razansky
1,2,*
Author Affiliations
Abstract
1
Institute of Pharmacology and Toxicology and Institute for Biomedical Engineering, Faculty of Medicine, University of Zurich, Zurich, Switzerland
2
Institute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH Zurich, Zurich, Switzerland
Applicability of optoacoustic imaging in biology and medicine is determined by several key performance characteristics. In particular, an inherent trade-off exists between the acquired field-of-view (FOV) and temporal resolution of the measurements, which may hinder studies looking at rapid biodynamics at the whole-body level. Here, we report on a single-sweep volumetric optoacoustic tomography (sSVOT) system that attains whole body three-dimensional mouse scans within 1.8 s with better than 200 μm spatial resolution. sSVOT employs a spherical matrix array transducer in combination with multibeam illumination, the latter playing a critical role in maximizing the effective FOV and imaging speed performance. The system further takes advantage of the spatial response of the individual ultrasound detection elements to mitigate common image artifacts related to limited-view tomographic geometry, thus enabling rapid acquisitions without compromising image quality and contrast. We compare performance metrics to the previously reported whole-body mouse imaging implementations and alternative image compounding and reconstruction strategies. It is anticipated that sSVOT will open new venues for studying large-scale biodynamics, such as accumulation and clearance of molecular agents and drugs across multiple organs, circulation of cells, and functional responses to stimuli.
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Photonics Research
2021, 9(6): 06000899
RESEARCH ARTICLE
Accounting for speed of sound variations in volumetric hand-held optoacoustic imaging
X. Luís DEáN-BEN
1,*
Ali OZBEK
1
Daniel RAZANSKY
1,2
作者单位
摘要
1
Institute of Biological and Medical Imaging (IBMI), Helmholtz Zentrum München, Neuherberg, Germany
2
School of Medicine and School of Bioengineering, Technical University of Munich, Munich, Germany
speed of sound (SoS)
graphics processing unit (GPU)
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Frontiers of Optoelectronics
2017, 10(3): 280
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